Rare case of COVID-19 vaccine-associated intracranial haemorrhage with venous sinus thrombosis

BMJ Case Rep. 2021 Sep 23;14(9):e245092. doi: 10.1136/bcr-2021-245092.

Abstract

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a relatively novel term which describes patients who have developed a low platelet count and prothrombotic tendencies secondary to receiving a vaccine. The concept has been derived from the well-established phenomenon of heparin-induced thrombocytopenia, and several cases of VITT have now been reported in patients who have received the AstraZeneca (ChAdOx1 nCov-19) vaccine. Unfortunately, some of these patients have gone on to develop intracranial venous sinus thrombosis. We present a case of VITT-associated sinus thrombosis secondary to the AstraZeneca (ChAdOx1 nCov-19) vaccine, which was complicated by a large intracerebral haemorrhage.

Keywords: COVID-19; global health; haematology (drugs and medicines); immunological products and vaccines; neuroimaging.

Publication types

  • Case Reports

MeSH terms

  • COVID-19 Vaccines
  • COVID-19*
  • ChAdOx1 nCoV-19
  • Humans
  • Intracranial Hemorrhages / chemically induced
  • Intracranial Hemorrhages / diagnostic imaging
  • SARS-CoV-2
  • Sinus Thrombosis, Intracranial* / chemically induced
  • Sinus Thrombosis, Intracranial* / diagnostic imaging
  • Vaccines*

Substances

  • COVID-19 Vaccines
  • Vaccines
  • ChAdOx1 nCoV-19