Figure 1
Development of human skin and lymphoid tissues in the human Skin and Immune System-humanized NSG mouse model. Transplantation of full-thickness human skin (derived from the scalp for skin with hair, or derived from dorsum for skin without hair) on the dorsum (A, B) and autologous lymphoid tissues in the kidney capsule (C) of NSG mice results in the engraftment and development of full-thickness human skin and lymphoid tissues. (A) Representative gross-photos at 0 (the day of transplantation), 2-, 4- and 10-weeks post-transplantation, with intact mouse skin as control (n = 4 per group). (B) Transplantation of full-thickness human skin from regions with significant hair follicles (scalp) in the human Skin and Immune System-humanized NSG mouse model results in the development of human hair, as exhibited in representative gross-photos at 12 weeks post-transplantation (n = 6). (C) Representative gross-photos of human lymphoid tissues (spleen and thymus tissues) and humanized lymphoid tissues (reconstituted-immunodeficient murine lymph node and spleen) at ten weeks post-transplantation (n = 4).
